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Alchemical Poisons

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Core Rulebook > Chapter 11: Crafting & Treasure > Crafting & Treasure > Alchemical Items

Alchemical poisons are potent toxins distilled or extracted from natural sources and made either stronger or easier to administer. Each poison’s stat block includes the Price and features for a single dose. Poison doses are typically kept in a vial or some other type of safe and secure container.

Applying alchemical poisons uses Interact actions. A poison typically requires one hand to pour into food or scatter in the air. Applying a poison to a weapon or another item requires two hands, with one hand holding the weapon or item. The Usage entry for a poison indicates the number of hands needed for a typical means of application, but the GM might determine that using poisons in other ways functions differently.

The full rules for how poisons and other afflictions work begin on page 457. A creature attempts the listed saving throw as soon as it’s exposed to the poison; on a failed save, the creature advances to stage 1 of the poison after any listed onset time elapses.

Some poisons have the virulent trait. This means the poison is harder to remove once it has taken effect; see Virulent Afflictions on page 458.

TABLE 1: ALCHEMICAL POISONS BY LEVEL
Level 0 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
alcoholGG ingested DC 12 Fortitude 1 day - fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 1 cp or more 1 L
bloodeye coffeeGG ingested DC 14 Fortitude 1 day 8 hours fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 5 sp 1 L
flayleafGG ingested or inhaled DC 12 Fortitude 1 day 4 hours fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 1 1 L
Level 1 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
arsenic ingested DC 18 Fortitude 10 min 5 min 1d4 poison damage and sickened 1 (1 minute) 1d6 poison damage and sickened 2 (1 minute) 2d6 poison damage and sickened 3 (1 minute) - 3 1 L
blood sapGG ingested DC 16 Fortitude 1 day 3 hours fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 4 1 L
giant centipede venom injury DC 17 Fortitude - 6 rounds 1d6 poison damage (1 round) 1d8 poison damage and flat-footed (1 round) 1d12 poison damage, clumsy 1, and flat-footed (1 round) - 4 2 L
ugrolnaAE-01 ingested DC 13 Fortitude 1 day 8 hours fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 3 1 L
peshLOWG ingested or inhaled - 1 day 6 hours fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 2 1 L
refined peshGG ingested or inhaled DC 12 Fortitude 1 day 6 hours fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 2 1 L
spear frog poisonB2 injury DC 15 Fortitude - 6 rounds 1d4 poison damage (1 round) 1d6 poison damage and enfeebled 1 (1 round) - - 3 held, 2 L
Level 2 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
belladonna ingested DC 19 Fortitude 10 min 30 min dazzled (10 minutes) 1d6 poison damage and sickened 1 (10 minutes) 1d6 poison damage, confused, and sickened 1 (1 minute) - 5 1 L
black adder venom injury DC 18 Fortitude - 3 rounds 1d8 poison damage (1 round) 1d10 poison damage (1 round) 2d6 poison damage (1 round) - 6 2 L
ublack smear poisonB1 injury DC 16 Fortitude - 6 rounds 1d6 poison and enfeebled 1 (1 round) As stage 1 1d6 poison, and enfeebled 2 (1 round) - 5 2 L
ulethargy poison injury DC 18 Fortitude - 4 hours slowed 1 (1 round) slowed 1 (1 minute) unconscious with no Perception check to wake up (1 round) unconscious with no Perception check to wake up (1d4 hours). 7 2 L
ulooter’s lethargyAE-01 contact DC 19 Fortitude 1 min 1 hour reduce Bulk limit by 3 (1 minute) flat-footed, reduce Bulk limit by 4 (10 minutes) flat-footed, reduce Bulk limit by 5 (10 minutes) - 6 1 L
toad tearsB2 ingested DC 19 Fortitude 5 min 30 min stupefied 1 (10 minutes) stupefied 1 and confused (1 minute) - - 6 1 L
uyellow musk poisonB2 inhaled DC 16 Will - 2 rounds fascinated by the poison cloud (1 round) fascinated by the poison cloud, and can use no actions but to move closer to the cloud’s point of origin (1 round) - - 7 1 L
Level 3 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
ublue dragonfly poisonB1 ingested DC 17 Fortitude 10 min 30 min dazzled (10 minutes) dazzled and frightened 1 (10 minutes) frightened 1 and confused 1 (1 minute) - 7 1 L
cytillesh oil injury DC 19 Fortitude - 4 rounds 1d10 poison damage (1 round) 1d12 poison damage (1 round) 2d10 poison damage (1 round) - 10 1 L
uforgetful dropsDA ingested or ingested DC 18 Fortitude 5 min 1 hour stupefied 1 (10 minutes) stupefied 1 and clumsy 1 (20 minutes) stupefied 1, clumsy 1, and confused (30 minutes) - 10 1 1
graveroot injury DC 19 Fortitude - 4 rounds 1d10 poison damage (1 round) 1d12 poison damage and stupefied 1 (1 round) 2d6 poison damage and stupefied 2 (1 round) - 10 2 L
shiverGG ingested DC 19 Fortitude 1 day 4 hours fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 10 1 L
uviolet venomB2 contact DC 17 Fortitude 1 min 6 rounds 1d6 poison plus enfeebled 1 (1 round) 1d6 poison plus drained 1 (1 round) 2d6 poison plus enfeebled 1 (1 round) - 12 2 L
Level 4 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
dreamtime teaGG ingested DC 21 Fortitude 1 day 30 min fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 13 1 L
leadenlegAPG injury DC 20 Fortitude - 6 rounds 1d10 poison damage and –5-foot status penalty to all Speeds (1 round) 2d6 poison damage and –10-foot status penalty to all Speeds (1 round) 2d6 poison damage and –20-foot status penalty to all Speeds (1 round) - 15 2 L
uspider moldOS-02 ingested DC 20 Fortitude 10 min 8 hours slowed 1 (1 round) slowed 2 and stupefied 1 (1 round) paralyzed and stupefied 1 (1 round) unconscious with no Perception check to wake up (1d4 hours). 20 2 L
ustupor poisonAV-03 injury DC 20 Fortitude - 6 hours slowed 1 and flat-footed (1 round) slowed 2 and flat-footed (1 round) unconscious with no Perception check to wake up (1 round) unconscious with no Perception check to wake up (1d6 hours) 16 2 L
zerkGG injury DC 20 Fortitude 1 day 1 hour fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 20 1 L
Level 5 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
ucytilleshGG ingested DC 15 Fortitude 1 day 8 hours fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 30 1 L
udiluted hypeLOL ingested DC 21 Fortitude 1 day 1 min fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 20 1 L
elven absintheGG ingested DC 20 Fortitude 1 day 1 day fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 25 1 L
ufalse deathAA-05 ingested DC 18 Fortitude 10 min 5 days clumsy 2 (1 round) unconscious (1 hour) unconscious (1 day) - 25 1 L
hunting spider venom injury DC 21 Fortitude - 6 rounds 1d10 poison damage and flat-footed (1 round) 1d12 poison damage, clumsy 1, and flat-footed (1 round) 2d6 poison damage, clumsy 2, and flat-footed (1 round) - 25 2 L
Level 6 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
uforgetful inkST-01 contact DC 20 Fortitude (secret) 1 min - The reader forgets the contents of the writing, recalling it as blank or as inconsequential text. - - - 32 2 L
giant scorpion venom injury DC 22 Fortitude - 6 rounds 1d10 poison damage and enfeebled 1 (1 round) 2d10 poison damage and enfeebled 1 (1 round) 2d10 poison damage and enfeebled 2 (1 round) - 40 2 L
Level 7 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
raddlebrainAA-03 inhaled DC 25 Fortitude 1 min 1 day enfeebled 1 and stupefied 1 (10 minutes) enfeebled 2 and stupefied 2 (1 hour) fatigued, enfeebled 4, and stupefied 4 (1 day) - 58 2 L
giant wasp venom injury DC 25 Fortitude - 6 rounds 2d6 poison damage and clumsy 1 (1 round) 3d6 poison damage and clumsy 2 (1 round) 4d6 poison damage and clumsy 2 (1 round) - 55 2 L
uisolation draughtAA-05 ingested DC 25 Fortitude 10 min 30 min dazzled, –3 to all Perception checks (1 minute) dazzled, deafened, –5 to all Perception checks (1 minute) blinded, deafened, –5 to all Perception checks (5 minutes) - 55 1 L
uknockout dramAE-01 ingested DC 23 Fortitude 1 min 10 hours fall unconscious and can’t attempt Perception checks to wake up (1 minute) sleep normally (1d4 hours) - - 70 1 L
malyass root paste contact DC 26 Fortitude 1 min 6 min clumsy 1 and –10-foot status penalty to all Speeds (1 minute) clumsy 2 and –20-foot status penalty to all Speeds (1 minute) clumsy 3, flat-footed, and –30-foot status penalty to all Speeds - 55 2 L
rsloughing toxinAV-02 injury DC 25 Fortitude 1 round 1 hour 1d6 poison damage for each action with the attack or move trait the victim uses (1 round) 1d6 poison damage and 1d6 slashing damage for each action with the attack, manipulate, or move trait the victim uses (1 round) as Stage 2, but 1d6 poison damage and 2d6 slashing damage, and forced movement also causes damage (1 hour) - 60 2 L
Level 8 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
rhypeLOL ingested DC 25 Fortitude 1 day 1 min fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 100 1 L
nettleweed residue contact DC 27 Fortitude 1 min 6 min 8d6 poison damage (1 minute) 10d6 poison damage (1 minute) 13d6 poison damage (1 minute) - 75 2 L
uscourGG ingested or inhaled DC 25 Fortitude 1 day 6 hours fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 80 1 L
wyvern poison injury DC 26 Fortitude - 6 rounds 5d6 poison damage (1 round) 6d6 poison damage (1 round) 8d6 poison damage (1 round) - 80 2 L
Level 9 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
rabysium powderLOTGB contact DC 27 Fortitude 1 min 6 min 8d6 poison damage and sickened 1 (1 minute) 9d6 poison damage and sickened 2 (1 minute) 10d6 poison damage and sickened 3 (1 minute)

Craft Requirements abysium worth at least 75 gp.

- 150 2 L
lich dust ingested DC 28 Fortitude 10 min 6 min fatigued (1 minute) 5d6 poison damage and fatigued (1 minute) 5d6 poison damage, fatigued, and paralyzed (1 minute) - 110 1 L
spider root contact DC 28 Fortitude 1 min 6 min 8d6 poison damage and clumsy 1 (1 minute) 9d6 poison damage and clumsy 2 (1 minute) 10d6 poison damage and clumsy 3 (1 minute) - 110 2 L
uterror sporesSKT-03 inhaled or inhaled DC 28 Fortitude 1 round 6 rounds frightened 2 (1 round) frightened 3 (1 round) frightened 3 and fleeing for 1 round (1 round) - 110 1 L
Level 10 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
razure lily pollenPKAP-PG inhaled or inhaled DC 28 Fortitude - 6 rounds 2d6 mental damage (1 round) 3d6 mental damage (1 round) 3d6 mental damage and slowed 1 (1 round) 3d6 mental damage, slowed 1, and confused (1 round). 200 1 L
rhoneyscentLOL inhaled DC 30 Will - 6 rounds 2d6 slashing damage (1 round) 2d6 slashing damage and stupefied 1 (1 round) 2d6 slashing damage, drained 1, and stupefied 1 - 180 1 L
shadow essence injury DC 29 Fortitude - 6 rounds 3d6 negative damage and 2d6 poison damage (1 round) 3d6 negative damage, 2d6 poison damage, and enfeebled 1 (1 round) 3d6 negative damage, 2d6 poison damage, and enfeebled 2 (1 round) - 160 2 L
rtoxic effluenceSKT-03 contact or contact DC 29 Fortitude - 6 rounds 3d6 poison damage, 3d6 fire damage, clumsy 1, and enfeebled 1 (1 round) 4d6 poison damage, 4d6 fire damage, clumsy 2, and enfeebled 2 (1 round) 5d6 poison damage, 5d6 fire damage, clumsy 3, and enfeebled 3 (1 round) - 160 2 L
wolfsbane ingested DC 30 Fortitude 10 min 6 min 12d6 poison damage (1 minute) 16d6 poison damage (1 minute) 20d6 poison damage (1 minute) - 155 1 L
Level 11 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
blightburn resin contact DC 31 Fortitude 1 min 6 rounds 8d6 poison damage (1 round) 10d6 poison damage (1 round) 15d6 poison damage (1 round) - 225 2 L
Level 12 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
rblackfinger blightAE-03 contact DC 32 Fortitude 1 round 6 rounds 6d6 poison damage (1 round) 8d6 poison damage (1 round) 10d6 poison damage and confused (1 round) - 350 1 L
umage baneAA-05 injury DC 32 Fortitude - 6 rounds 2d6 mental damage and stupefied 2 (1 round) 3d6 mental damage and stupefied 3 (1 round) 4d6 mental damage and stupefied 4 (1 round) - 325 2 L
rplasma hypeLOL ingested DC 30 Fortitude 1 day 1 min fatigued (1 week) fatigued and sickened 1 (1 week) fatigued, drained 1, and sickened 1 (1 week) fatigued, drained 2, sickened 2, and stupefied 2 (1 week) 400 1 L
slumber wine ingested DC 32 Fortitude 1 hour 7 days unconscious (1 day) unconscious (2 days) unconscious (3 days). - 325 1 L
Level 13 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
deathcap powder ingested DC 33 Fortitude 10 min 6 min 13d6 poison damage (1 minute) 17d6 poison damage and sickened 2 (1 minute) 20d6 poison damage and sickened 3 (1 minute) - 450 1 L
ugorgon’s breathAA-05 inhaled DC 32 Fortitude 1 round 6 rounds slowed 1 (1 round) 4d6 bludgeoning damage and slowed 1 (1 round) petrified (1 round) petrified permanently 475 1 L
purple worm venom injury DC 32 Fortitude - 6 rounds 5d6 poison damage and enfeebled 2 (1 round) 6d6 poison damage and enfeebled 2 (1 round) 8d6 poison and enfeebled 2 (1 round) - 500 2 L
Level 15 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
dragon bile contact DC 37 Fortitude 1 min 6 rounds 6d6 poison damage and sickened 2 (1 round) 7d6 poison damage and sickened 3 (1 round) 9d6 poison damage and sickened 4 (1 round) - 925 2 L
mindfog mist inhaled DC 35 Fortitude 1 round 6 rounds stupefied 2 (1 round) confused and stupefied 3 (1 round) confused and stupefied 4 (1 round) - 1,000 1 L
Level 16 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
brimstone fumes inhaled DC 36 Fortitude 1 round 6 rounds 7d6 poison damage and enfeebled 1 (1 round) 8d6 poison damage and enfeebled 2 (1 round) 10d6 poison damage and enfeebled 3 (1 round) - 1,500 1 L
cerulean scourgeAPG injury DC 36 Fortitude - 6 rounds 9d6 poison damage (1 round) 12d6 poison damage (1 round) 15d6 poison damage (1 round) - 1,450 2 L
ufrenzy oilAA-05 contact DC 37 Fortitude 1d6 min 6 rounds 4d6 mental damage, quickened 1, attack nearby creatures as if confused (1 round) 6d6 mental damage, attack nearby creatures as if confused (1 round) 8d6 mental damage, fatigued, attack nearby creatures as if confused (1 round) - 1,500 1 L
nightmare vapor inhaled DC 36 Fortitude 1 round 6 rounds confused (1 round) confused and flat-footed (1 round) confused, flatfooted, and stupefied 2 (1 round) - 1,400 1 L
uweeping midnightAA-05 injury DC 36 Fortitude - 6 rounds 6d6 poison damage and dazzled (1 round) 7d6 poison damage, dazzled, and sickened 1 (1 round) 8d6 poison damage and blinded (1 round) - 1,400 2 L
Level 17 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
hemlock ingested DC 40 Fortitude 30 min 60 min 17d6 poison damage and enfeebled 2 (10 minutes) 21d6 poison damage and enfeebled 3 (10 minutes) 26d6 poison damage and enfeebled 4 (10 minutes) - 2,250 1 L
Level 18 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
king’s sleep ingested DC 41 Fortitude 1 day - drained 1 (1 day) drained 1 (1 day) drained 2 (1 day) - 4,000 1 L
Level 19 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
black lotus extract contact DC 42 Fortitude 1 min 6 rounds 15d6 poison damage and drained 1 (1 round) 17d6 poison damage and drained 1 (1 round) 20d6 poison damage and drained 2 (1 round) - 6,500 1 L
uoblivion essenceAA-05 injury DC 42 Fortitude - 6 rounds 8d6 poison damage and slowed 1 (1 round) 10d6 poison damage, enfeebled 2, and slowed 1 (1 round) 12d6 poison damage, enfeebled 3, slowed 1 (1 round) - 6,500 2 L
Level 20 Poison Type DC Onset Max Dur Stage 1 Stage 2 Stage 3 Stage 4 Price (gp) Usage Bulk Activate
rnightmare saltAA-05 ingested DC 43 Fortitude 1 hour 5 days frightened 2 once every 1d4 hours, plus fatigued (1 day) confused for 1 minute once every 1d4 hours, plus frightened 3 and fatigued (1 day) frightened 3, plus confused for 1d4 minutes, once every hour, plus fatigued (1 day) death 14,000 2 L
tears of death contact DC 46 Fortitude 1 min 10 min 18d6 poison damage and paralyzed (1 round) 25d6 poison damage and paralyzed (1 minute) 30d6 poison damage and paralyzed (1 minute) - 12,000 2 L